ParkinsonCanadaV1, Main, Exploration, bibRecord, 001819

Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions

Identifieur interne : 001819 ( Main/Exploration ); précédent : 001818; suivant : 001820

Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions

Auteurs : Janelle Drouin-Ouellet ; Anna-Liisa Brownell ; Martine Saint-Pierre ; Caroline Fasano ; Vincent Emond ; Louis-Eric Trudeau ; Daniel Lévesque ; Francesca Cicchetti [Canada]

Source :

Glia [ 0894-1491 ] ; 2011-02.

RBID : ISTEX:19A71D32EF80427BA483D23B6427B76A7205ECD0

English descriptors

KwdEn :
- activated microglia, astrocytes, metabotropic glutamate receptor type 5 (mGluR5), ibotenic acid, minocycline, neonatal ventral hippocampal lesion.

Abstract

It has been hypothesized that neuroinflammation triggered during brain development can alter brain functions later in life. We investigated the contribution of inflammation to the alteration of normal brain circuitries in the context of neuroexcitotoxicity following neonatal ventral hippocampal lesions in rats with ibotenic acid, an NMDA glutamate receptor agonist. Excitotoxic ibotenic acid lesions led to a significant and persistent astrogliosis and microglial activation, associated with the production of inflammatory mediators. This response was accompanied by a significant increase in metabotropic glutamate receptor type 5 (mGluR5) expression within two distinct neuroinflammatory cell types; astrocytes and microglia. The participation of inflammation to the neurotoxin‐induced lesion was further supported by the prevention of hippocampal neuronal loss, glial mGluR5 expression and some of the behavioral perturbations associated to the excitotoxic lesion by concurrent anti‐inflammatory treatment with minocycline. These results indicate that neuroinflammation significantly contributes to long‐lasting excitotoxic effects of the neurotoxin and to some behavioral phenotypes associated with this model. Thus, the control of the inflammatory response may prevent the deleterious effects of excitotoxic processes that are triggered during brain development, limiting the risk to develop some of the behavioral manifestations related to these processes in adulthood. © 2010 Wiley‐Liss, Inc.

Url:

DOI: 10.1002/glia.21086

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">It has been hypothesized that neuroinflammation triggered during brain development can alter brain functions later in life. We investigated the contribution of inflammation to the alteration of normal brain circuitries in the context of neuroexcitotoxicity following neonatal ventral hippocampal lesions in rats with ibotenic acid, an NMDA glutamate receptor agonist. Excitotoxic ibotenic acid lesions led to a significant and persistent astrogliosis and microglial activation, associated with the production of inflammatory mediators. This response was accompanied by a significant increase in metabotropic glutamate receptor type 5 (mGluR5) expression within two distinct neuroinflammatory cell types; astrocytes and microglia. The participation of inflammation to the neurotoxin‐induced lesion was further supported by the prevention of hippocampal neuronal loss, glial mGluR5 expression and some of the behavioral perturbations associated to the excitotoxic lesion by concurrent anti‐inflammatory treatment with minocycline. These results indicate that neuroinflammation significantly contributes to long‐lasting excitotoxic effects of the neurotoxin and to some behavioral phenotypes associated with this model. Thus, the control of the inflammatory response may prevent the deleterious effects of excitotoxic processes that are triggered during brain development, limiting the risk to develop some of the behavioral manifestations related to these processes in adulthood. © 2010 Wiley‐Liss, Inc.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions

Neuroinflammation is associated with changes in glial mGluR5 expression and the development of neonatal excitotoxic lesions

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
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